Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription

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Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription.

Sodium/hydrogen exchangers (NHEs) play a major role in Na(+) absorption, cell volume regulation, and intracellular pH regulation. Of the nine identified mammalian NHEs, three (NHE2, NHE3, and NHE8) are localized on the apical membrane of epithelial cells in the small intestine and the kidney. Although the regulation of NHE2 and NHE3 expression has been extensively studied in the past decade, li...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Cell Physiology

سال: 2010

ISSN: 0363-6143,1522-1563

DOI: 10.1152/ajpcell.00081.2010